Phenotypes Associated with This Genotype

Genotype
MGI:3703596

• Allelic Composition: Ms4a2^tm1Knt/Ms4a2^tm1Knt
• Genetic Background: involves: 129 * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:47138 )

• after stimulation with 2.4G2, very little bone marrow mast cell degranulation is observed

decreased susceptibility to type I hypersensitivity reaction ( J:47138 )

• injection of 2.4G2 to induce anaphylaxis results in a smaller decrease in rectal temperature ( 2 degrees) compared to Fcer1a-deficient mice (8 degrees) or wild-type mice (4 degrees)

abnormal cytokine secretion ( J:47138 )

• Il-6 production in stimulated BMMCs is reduced compared to Fcer1a-null mice

hematopoietic system

abnormal mast cell physiology ( J:47138 )

• after stimulation with 2.4G2, very little bone marrow mast cell degranulation is observed