About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3703450
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• significantly more sperm with head abnormalities
• significantly reduced frequencies of sperm with progressive motility
• Leydig cells are clustered loosely in expanded interstitial compartment
• only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
• testes are 37.9% of control testes weights (J:96650)
• significantly smaller testes than controls (J:117029)
• spermatocytes beyond pachytene stage and round spermatids are significantly reduced in number, while elongated spermatids are rare and remaining spermatids have deformed nuclei (J:96650)
(J:117029)
• sperm concentration was significantly reduced below controls
• many tubules contain germ cells in arrested at meiotic metaphase 1
• presence of an intact extra chromosome interferes with chromosome pairing in meiosis
• produced no progeny
• fail to produce a vaginal plug

cellular
• significantly more sperm with head abnormalities
• sperm concentration was significantly reduced below controls
• significantly reduced frequencies of sperm with progressive motility

growth/size/body
• mice are ~20% smaller in size compared to normal littermates postnatally

nervous system
• dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
• the area of presynaptic elements (p38+) is increased in the fascia dentate and motor cortex
• in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40% in the cortex
• 18% of dendritic spines are enlarged and display irregular heads or a globular shape
• average synapse length is increased 34% in the hippocampus and 25% in the cortex
• glutamatergic synapses are distributed 33% on the dendritic shaft (compared to 51% in wild-type mice) and 67% (compared to 49% in wild-type mice) on the heads or necks of the dendritic spines
• in fascia dentate, spine density is significantly decreased on dendrites of granule cells; dendritic spines are significantly enlarged; dendritic width is similar to controls
• dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
• 18% of spines are enlarged and display irregular heads or a globular shape
• basal dentritic spine density in CA1 is increased

endocrine/exocrine glands
• Leydig cells are clustered loosely in expanded interstitial compartment
• only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
• testes are 37.9% of control testes weights (J:96650)
• significantly smaller testes than controls (J:117029)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:94569 , J:96650


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/30/2021
MGI 6.17
The Jackson Laboratory