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Phenotypes Associated with This Genotype
Genotype
MGI:3702323
Allelic
Composition
Msx1tm1Bero/Msx1tm1Bero
Genetic
Background
B6.129P2-Msx1tm1Bero
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• newborn homozygotes die within a few hours after birth
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes die more rapidly than homozygotes on mixed genetic background

craniofacial
• at birth, homozygotes exhibit a rounded skull
• newborn homozygotes lack alveolar processes
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin
• newborn homozygotes lack incisors
• at P0, homozygotes lack mandibular molars
• molars develop until E13.5 and reach the bud stage but fail to develop further
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities
• at ~E13, the shape of the secondary palate is slightly altered
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• at birth, homozygotes display a shortened snout
• at birth, homozygotes display a shortened head

respiratory system
• newborns exhibit gasping respirations prior to death and contain air in their stomachs and intestines
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes contain less air in their stomachs than homozygotes on a mixed genetic background

homeostasis/metabolism
• newborn homozygotes become rapidly cyanotic

skeleton
• at birth, homozygotes exhibit a rounded skull
• newborn homozygotes lack alveolar processes
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin
• newborn homozygotes lack incisors
• at P0, homozygotes lack mandibular molars
• molars develop until E13.5 and reach the bud stage but fail to develop further
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities

digestive/alimentary system
• at ~E13, the shape of the secondary palate is slightly altered
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)

hearing/vestibular/ear
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities

limbs/digits/tail
N
• surprisingly, homozygotes exhibit no limb defects

growth/size/body
• newborn homozygotes lack incisors
• at P0, homozygotes lack mandibular molars
• molars develop until E13.5 and reach the bud stage but fail to develop further
• at ~E13, the shape of the secondary palate is slightly altered
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• at birth, homozygotes display a shortened snout
• at birth, homozygotes display a shortened head

Mouse Models of Human Disease
OMIM ID Ref(s)
Tooth Agenesis, Selective, 1; STHAG1 106600 J:42035


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory