Mouse Genome Informatics
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    Msx1tm1Bero/Msx1tm1Bero
B6.129P2-Msx1tm1Bero
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• newborn homozygotes die within a few hours after birth
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes die more rapidly than homozygotes on mixed genetic background

craniofacial
• at birth, homozygotes exhibit a rounded skull
• newborn homozygotes lack alveolar processes
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities
• molars develop until E13.5 and reach the bud stage but fail to develop further
• at ~E13, the shape of the secondary palate is slightly altered
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• newborn homozygotes lack incisors
• at P0, homozygotes lack mandibular molars
• at birth, homozygotes display a shortened snout
• at birth, homozygotes display a shortened head

respiratory system
• newborns exhibit gasping respirations prior to death and contain air in their stomachs and intestines
• Background Sensitivity: on a congenic C57BL/6J background, newborn homozygotes contain less air in their stomachs than homozygotes on a mixed genetic background

homeostasis/metabolism
• newborn homozygotes become rapidly cyanotic

skeleton
• at birth, homozygotes exhibit a rounded skull
• newborn homozygotes lack alveolar processes
• at ~E13, mandibular development is slightly delayed, resulting in a cleft chin
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities

digestive/alimentary system
• at ~E13, the shape of the secondary palate is slightly altered
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)

hearing/vestibular/ear
• newborn homozygotes lack the short process of the malleus, in the absence of other ear abnormalities

limbs/digits/tail
N
• surprisingly, homozygotes exhibit no limb defects (J:42035)

growth/size/body
• molars develop until E13.5 and reach the bud stage but fail to develop further
• at ~E13, the shape of the secondary palate is slightly altered
• all newborn homozygotes show a complete cleft of the secondary palate (J:42035)
• newborn homozygotes lack incisors
• at P0, homozygotes lack mandibular molars
• at birth, homozygotes display a shortened snout
• at birth, homozygotes display a shortened head

Mouse Models of Human Disease
OMIM IDRef(s)
Tooth Agenesis, Selective, 1; STHAG1 106600 J:42035