About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3702078
Allelic
Composition
Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnl3Gt(W223E05)Wrst mutation (0 available); any Gnl3 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most embryos die before implantation
• at E4.5 all homozygotes show varying degrees of deterioration
• a few highly abnormal and underdeveloped embryos survive until just after implantation

embryo
• no hatched embryos are found at E4.5
• at the blastocyst stage
• at E3 embryos contain about half as many nuclei as control littermates
• from E3 to E3.5 no increase in the number of cells in the embryo is seen compared to a doubling of the number of cells in control littermates over the same time span
• however nuclei are morphologically normal suggesting no defect in mitosis is present and no increase in the number of apoptotic cell is detected

cellular
• at E3.0 - E3.5 cells in the blastocyst fail to enter the S-phase of the cell cycle
• at E3.0 - E3.5 almost no BrdU incorporation is seen indicating a significant impairment in proliferation in the whole embryo
• from E3 to E3.5 no increase in the number of cells in the embryo is seen compared to a doubling of the number of cells in control littermates over the same time span


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory