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Phenotypes Associated with This Genotype
Genotype
MGI:3702076
Allelic
Composition
Il15ratm1Ama/Il15ratm1Ama
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit little if any proliferation while stimulation with 50 ng/mL induces reduced proliferation compared to similarly treated wild-type cells
• however, stimulation of TCR-activated CD8+ T cells with 500 ng/mL IL15 induces normal proliferation
• donor CD4+ and CD8+ T cells transplanted into irradiated wild-type mice exhibit reduced cell-cycle progression compared to donor wild-type cellsdonor CD4+ and CD8+ T cells transplanted into irradiated wild-type mice exhibit reduced cell-cycle progression compared to donor wild-type cells

immune system
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit little if any proliferation while stimulation with 50 ng/mL induces reduced proliferation compared to similarly treated wild-type cells
• however, stimulation of TCR-activated CD8+ T cells with 500 ng/mL IL15 induces normal proliferation
• donor CD4+ and CD8+ T cells transplanted into irradiated wild-type mice exhibit reduced cell-cycle progression compared to donor wild-type cellsdonor CD4+ and CD8+ T cells transplanted into irradiated wild-type mice exhibit reduced cell-cycle progression compared to donor wild-type cells
• in 6 to 12 week-old mice, percentages of NK cells in spleen and bone marrow (BM) or mutants are extremely low (J:119213)
• however, when spleen and BM progenitors are cultured with appropriate factors (Il-7, SCF, flt3) followed by Il-15, they can differentiate into functional NK cells, if transplanted into wild-type recipients, spleen and BM cells can differentiate in vivo to NK cells (J:119213)
• mice exhibit a reduction in splenic NK cells compared to in wild-type mice (J:142570)
• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice
• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice
• mice exhibit a reduction in CD44highIL23beta+CD8+ memory T cells compared to in wild-type mice
• NK cells generated in vitro do not express Ly-49 receptors as normal NK cells do; NK cells differentiated in vivo from transplanted mutant splenic and BM cells show much lower expression of Ly-49 than wild-type NK cells
• mice have no cytolytic NK activity

hematopoietic system
• TCR-activated CD8+ T cells stimulated with 5 ng/mL IL15 exhibit little if any proliferation while stimulation with 50 ng/mL induces reduced proliferation compared to similarly treated wild-type cells
• however, stimulation of TCR-activated CD8+ T cells with 500 ng/mL IL15 induces normal proliferation
• donor CD4+ and CD8+ T cells transplanted into irradiated wild-type mice exhibit reduced cell-cycle progression compared to donor wild-type cellsdonor CD4+ and CD8+ T cells transplanted into irradiated wild-type mice exhibit reduced cell-cycle progression compared to donor wild-type cells
• in 6 to 12 week-old mice, percentages of NK cells in spleen and bone marrow (BM) or mutants are extremely low (J:119213)
• however, when spleen and BM progenitors are cultured with appropriate factors (Il-7, SCF, flt3) followed by Il-15, they can differentiate into functional NK cells, if transplanted into wild-type recipients, spleen and BM cells can differentiate in vivo to NK cells (J:119213)
• mice exhibit a reduction in splenic NK cells compared to in wild-type mice (J:142570)
• mice exhibit a reduction in CD8+ T cells compared to in wild-type mice
• mice exhibit a reduction in NKT and thymic NKT cells compared to in wild-type mice
• mice exhibit a reduction in CD44highIL23beta+CD8+ memory T cells compared to in wild-type mice
• NK cells generated in vitro do not express Ly-49 receptors as normal NK cells do; NK cells differentiated in vivo from transplanted mutant splenic and BM cells show much lower expression of Ly-49 than wild-type NK cells
• mice have no cytolytic NK activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory