mortality/aging
• no homozygous mutants are born; between E5.5 and E7.5, normal-appearing embryos and empty deciduae are found, suggesting early post-implantation homozygous lethality
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embryo
• inner cell mass cells of homozygous blastocysts often do not hatch after 4 days and degenerate soon afterwards
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nervous system
• prepulse inhibition response is abnormal in heterozygous mice; percent inhibition is significantly higher than in controls
• Background Sensitivity: levels of prepulse inhibition are higher at the 2 highest prepulse sound levels than on mixed 129S6/Black Swiss) background
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behavior/neurological
cardiovascular system
N |
• mutants do not show abnormal development of cardiovascular system and do not show signs of DiGeorge Syndrome or VCS
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