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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous fibroblasts senesce approximately one passage earlier than controls
• however, homozygotes do not show any overt histological signs of accelerated senescence, are capable of living beyond 2 years of age, and cells do not show increased susceptibility to the genotoxins camptothecin or 4-NQO
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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