Phenotypes for Kcne2 MGI:3700741 MGI Mouse

abnormal stomach glandular region morphology ( J:116518 )

• marked hyperplasia of the glandular stomach

abnormal gastric parietal cell morphology ( J:116518 )

• intracellular canaliculi are much larger and displace the mitochondria to the cell periphery

• however, no obvious abnormalities in the chief cells are detected

• gastric glandular hyperplasia with lengthening of the fundus and neck portions of the stomach

• hyperplastic glands are primarily lined with tall, columnar cells with excess cytoplasm that appear to be mucous neck and/or chief cells

• hyperplasia appears to only affect the non-acid secretory cell types

abnormal stomach glandular epithelium morphology ( J:116518 )

• mild to moderate numbers of neutrophils are seen scattered through the lamina propria basally, submucosa, and muscularis

enlarged stomach ( J:116518 )

• at 12 - 15 weeks of age about a 4-fold increase in stomach mass is seen

• enlarged stomachs have prominent rugal folds and marked hyperplasia of the glandular stomach

achlorhydria ( J:116518 )

• mice display achlorhydria

decreased digestive secretion ( J:116518 )

• acid loaded parietal cells have a much lower rate of proton secretion, about 0.01 pH units/minute compared to about 0.1 units/minute in wild-type controls

increased stomach pH ( J:116518 )

• mean luminal pH in the stomach under basal conditions is 6.5 +/- 0.2 compared to 3.9 +/- 0.1 in wild-type controls

• luminal pH is not significantly altered by histamine, unlike in wild-type controls

increased circulating gastrin level ( J:116518 )

• marked elevation in serum gastrin levels