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Phenotypes Associated with This Genotype
Genotype
MGI:3700260
Allelic
Composition
Chrna4tm2Jbou/Chrna4+
Genetic
Background
either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna4tm2Jbou mutation (1 available); any Chrna4 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• observed during seizures
• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

nervous system
• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over
• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 5.1% of a 4-hour recording period


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory