Phenotypes Associated with This Genotype

Genotype
MGI:3700177

• Allelic Composition: Supt20^{Gt(RRK304)Byg}/Supt20^{Gt(RRK304)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

embryonic growth retardation ( J:106348 )

• E9.5 and E10.5 embryos are developmentally delayed

embryo

abnormal vitelline vasculature morphology ( J:106348 )

• yolk sac membranes are poorly vascularized

embryo tissue necrosis ( J:106348 )

abnormal developmental patterning ( J:106348 )

• midline marker analysis indicates that midline is present in embryos but is often severely disrupted and discontinuous

abnormal mesoderm development ( J:106348 )

• mesoderm is properly specified at E8.5, as indicated by marker analysis, but it is disorganized

• mutant mesoderm undergoes a partial epithelial to mesenchymal transition (EMT), however it fails to complete EMT

abnormal left-right axis symmetry of the somites ( J:106348 )

• often the paraxial mesoderm is not divided into discrete left and right domains

embryonic growth retardation ( J:106348 )

• E9.5 and E10.5 embryos are developmentally delayed

abnormal paraxial mesoderm morphology ( J:106348 )

• often the paraxial mesoderm is not divided into discrete left and right domains

abnormal head fold morphology ( J:106348 )

• mutants exhibit misshapen head folds

abnormal primitive streak morphology ( J:106348 )

• a significant proportion of the mesoderm fails to migrate away from the primitive streak

• E7.5 primitive streak mesoderm cells do not migrate away from explants when grown in culture

incomplete somite formation ( J:106348 )

• homozygotes fail to form somites or form only a few anterior somites; presomitic mesoderm is specified as indicated by marker analysis, although it is not organized into somitomeres

abnormal allantois morphology ( J:106348 )

• embryos develop a malformed allantois

abnormal visceral yolk sac morphology ( J:106348 )

• yolk sac membranes are wrinkled

failure of chorioallantoic fusion ( J:106348 )

• embryos develop a malformed allantois that fails to fuse to the chorion

nervous system

exencephaly ( J:106348 )

cardiovascular system

abnormal vitelline vasculature morphology ( J:106348 )

• yolk sac membranes are poorly vascularized

cellular

embryo tissue necrosis ( J:106348 )