Phenotypes Associated with This Genotype

Genotype
MGI:3700137

• Allelic Composition: Trp53^tm5Wahl/Trp53^tm5Wahl
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:118244 )

N • no significant loss of homozygotes is detected

cellular

cellular phenotype ( J:118244 )

N • MEFs arrest after exposure to 6 Gy or 12 Gy irradiation similar to wild-type MEFs and unlike Trp53 null cells

N • sensitivity to adriamycin-induced apoptosis is similar to wild-type MEFs, unlike Trp53 null cells which show increased resistance

N • thymocyte sensitivity to gamma-irradiation-induced apoptosis is similar to wild-type cells unlike Trp53^tm3Wahl homozygotes which show increased resistance