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Phenotypes Associated with This Genotype
Genotype
MGI:3700037
Allelic
Composition
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2tm1Ayos mutation (1 available); any Spry2 mutation (11 available)
Spry4tm1Ayos mutation (1 available); any Spry4 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die by E12.5 (J:116506)
• most die by E12.5 (J:116506)

vision/eye

craniofacial
• craniofacial abnormalities (J:116506)
• craniofacial abnormalities (J:116506)

limbs/digits/tail
• limb abnormalities (J:116506)
• limb abnormalities (J:116506)

nervous system
• severe truncation of the forebrain and cephalic neural crest-derived head tissues (J:116506)
• severe truncation of the forebrain and cephalic neural crest-derived head tissues (J:116506)
• alobar brain development and cyclopia resemble holoprosencephaly (J:116506)
• alobar brain development and cyclopia resemble holoprosencephaly (J:116506)

respiratory system
• exhibit abnormalities of the lung pattern and epithelial branching (J:116506)
• exhibit abnormalities of the lung pattern and epithelial branching (J:116506)
• reduced number of airways (J:116506)
• reduced number of airways (J:116506)

Mouse Models of Human Disease
OMIM ID Ref(s)
Apert Syndrome 101200 J:116506


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory