Analysis Tools
mortality/aging
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• ~60% of homozygotes die during the third postnatal week
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growth/size/body
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• at 10 weeks of age, homozygotes show a 10.4% decrease in body weight relative to wild-type controls
• after a 24-hr water deprivation period, homozygotes show a greater body weight loss (30%) than wild-type controls (25%)
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• homozygotes display a delayed weight gain after 9 weeks of age
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• at 10 weeks of age, wet kidney weight relative to whole body weight is signifcantly increased relative to that in wild-type mice
• however, absolute kidney weight remains unchanged
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renal/urinary system
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• euhydrated homozygotes display a severe reduction in urinary excretion of aldosterone relative to wild-type controls
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• euhydrated homozygotes show a 2.9-fold increase in urinary excretion of vasopressin relative to wild-type controls
• after a 24-hr water deprivation period, homozygotes show a 5.5 increase in urinary excretion of vasopressin relative to wild-type controls
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• euhydrated homozygotes display significantly lower urinary concentrations of potassium than wild-type controls
• during a 24-hr water deprivation period, homozygotes fail to increase their urinary potassium levels, unlike wild-type controls
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• during a 24-hr water deprivation period, homozygotes fail to increase their urinary sodium levels, unlike wild-type controls
• euhydrated homozygotes display significantly lower urinary concentrations of sodium than wild-type controls
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• euhydrated homozygotes display reduced urine osmolarity relative to wild-type controls
• during a 24-hr water deprivation period, homozygotes fail to significantly increase their urine osmolarity, unlike in wild-type controls where urine osmolality is increased by 72%
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• at 10 weeks of age, homozygotes display chronic interstitial inflammation
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• similar to that observed in Agtr1atm1Unc Agtr1btm1Cof double homozygotes or Agtr1atm1Unc Agtr1btm1Cof Agtr2tm1Tin triple homozygotes
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• at 10 weeks of age, wall thickening of the afferent arterioles is observed
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• at 10 weeks of age, wall thickening of the interlobular arteries is observed
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• at 10 weeks of age, wet kidney weight relative to whole body weight is signifcantly increased relative to that in wild-type mice
• however, absolute kidney weight remains unchanged
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• at 10 weeks of age, the mean glomerular count per maximal cross sectional area is signifcantly reduced
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• at 10 weeks of age, homozygotes display papillary atrophy
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• at 10 weeks of age, homozygotes display a thinned kidney medulla relative to wild-type controls
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• at 10 weeks of age, homozygotes display a dilated renal pelvis
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• at 10 weeks of age, homozygotes display atrophic renal tubules
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• after a 24-hr water deprivation period, homozygotes show a signifcant decrease in creatinine clearance, unlike wild-type controls
• however, euhydrated homozygotes display normal endogenous creatinine clearance and plasma creatinine levels
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• euhydrated homozygotes show increased urine output relative to wild-type controls
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homeostasis/metabolism
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• euhydrated homozygotes display significantly higher plasma vasoperssin levels (4.3x) than wild-type controls
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• euhydrated homozygotes show a 70% reduction in mean plasma aldosterone levels relative to wild-type controls
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• euhydrated homozygotes display a severe reduction in urinary excretion of aldosterone relative to wild-type controls
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• euhydrated homozygotes show a 2.9-fold increase in urinary excretion of vasopressin relative to wild-type controls
• after a 24-hr water deprivation period, homozygotes show a 5.5 increase in urinary excretion of vasopressin relative to wild-type controls
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• euhydrated homozygotes display significantly lower urinary concentrations of potassium than wild-type controls
• during a 24-hr water deprivation period, homozygotes fail to increase their urinary potassium levels, unlike wild-type controls
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• euhydrated homozygotes display significantly lower urinary concentrations of sodium than wild-type controls
• during a 24-hr water deprivation period, homozygotes fail to increase their urinary sodium levels, unlike wild-type controls
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• euhydrated homozygotes display reduced urine osmolarity relative to wild-type controls
• during a 24-hr water deprivation period, homozygotes fail to significantly increase their urine osmolarity, unlike in wild-type controls where urine osmolality is increased by 72%
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cardiovascular system
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• at 10 weeks of age, wall thickening of the afferent arterioles is observed
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• at 10 weeks of age, wall thickening of the interlobular arteries is observed
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• exhibit impaired blood-brain barrier function as indicated by leakage of Evans blue dye after cold injury
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nervous system
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• exhibit impaired blood-brain barrier function as indicated by leakage of Evans blue dye after cold injury
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• the granular layer cells of the hippocampus have larger nuclei and are round shaped with coarse chromatin and the cellular density is decreased with less layers
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immune system
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• at 10 weeks of age, homozygotes display chronic interstitial inflammation
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