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Phenotypes Associated with This Genotype
Genotype
MGI:3697585
Allelic
Composition
Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• homozygotes from mothers that are treated with a blocking anti-C5 antibody throughout pregnancy survive to adulthood
• normal frequency of homozygotes until around E9.5
• all are dead by E16.5

embryo
• C3 (complement) deposited on the surface
• C3 (complement) deposited on the surface
• reduced deciduas at E9.5

immune system
• extensive invasion of polymorphonuclear inflammatory granulocytes around the ectoplacental cone and the trophoectoderm

reproductive system
• reduced deciduas at E9.5

nervous system
• 20 week-old mutants (from mothers treated with an anti-C5 antibody throughout pregnancy) show a reduction in complement factor H and a decrease in tau phosphorylation in the hippocampus, both markers of Alzheimer's disease


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory