Mouse Genome Informatics
involves: 129X1/SvJ
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• homozygotes from mothers that are treated with a blocking anti-C5 antibody throughout pregnancy survive to adulthood (J:197576)
• normal frequency of homozygotes until around E9.5
• all are dead by E16.5

• C3 (complement) deposited on the surface
• C3 (complement) deposited on the surface
• reduced deciduas at E9.5 (J:59432)

immune system
• extensive invasion of polymorphonuclear inflammatory granulocytes around the ectoplacental cone and the trophoectoderm

reproductive system
• reduced deciduas at E9.5 (J:59432)

nervous system
• 20 week-old mutants (from mothers treated with an anti-C5 antibody throughout pregnancy) show a reduction in complement factor H and a decrease in tau phosphorylation in the hippocampus, both markers of Alzheimer's disease