Phenotypes Associated with This Genotype

Genotype
MGI:3697502

• Allelic Composition: Ephb2^tm1Paw/Ephb2^tm1Paw
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:34200 )

• most axons forming the posterior tract of the anterior commissure migrate aberrantly as fasciculated bundles to the ventral floor of the forebrain, resulting in a failure of cortical neurons to link the two temporal lobes

abnormal anterior commissure pars posterior morphology ( J:34200 )

• all adult homozygotes show a significant reduction of the lateral projection of the anterior commissure (pars posterior), a major forebrain commissure that connects the two temporal lobes of the cortex, with a thickness of less than 100 m vs >300 m in wild type mice

• in contrast, the horseshoe-shaped tract that connects the two olfactory bulbs (pars anterior) appears normal

cellular

abnormal axon guidance ( J:34200 )

• most axons forming the posterior tract of the anterior commissure migrate aberrantly as fasciculated bundles to the ventral floor of the forebrain, resulting in a failure of cortical neurons to link the two temporal lobes