Phenotypes Associated with This Genotype

Genotype
MGI:3697483

• Allelic Composition: Atp1a2^tm2Ling/Atp1a2⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:117414 )

• increased latency to find the platform in a Morris water maze

increased anxiety-related response ( J:117414 )

• fewer entries into the open arms and less time spent in the open quadrants in an elevated zero maze

• less time spent in the center and more time spent in the corners of an open field and reduced movement in the first time period after being placed in an open field

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:117414 )

N • circulating levels of corticosterone, norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice