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Phenotypes Associated with This Genotype
Genotype
MGI:3697458
Allelic
Composition
Abca4tm1Ght/Abca4tm1Ght
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca4tm1Ght mutation (2 available); any Abca4 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• levels of lipofuscin and its associated metabolites are 20-fold higher than in controls in the retinal pigment epithelium of mice supplemented with vitamin A
• A2E fluorescent product (from condensation of all-trans-retinal) is detected at much higher levels than in wild-type or Rdh12-deficient mice

homeostasis/metabolism
• mice supplemented with vitamin A accumulate more higher levels of all-trans retinoic acid in both the liver and eyes

pigmentation
• levels of lipofuscin and its associated metabolites are 20-fold higher than in controls in the retinal pigment epithelium of mice supplemented with vitamin A


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory