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Phenotypes Associated with This Genotype
Genotype
MGI:3697388
Allelic
Composition
Dusp6tm1Sms/Dusp6+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp6tm1Sms mutation (0 available); any Dusp6 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected are found at weaning
• Background Sensitivity: with further crosses to C57BL/6 mice the number of mutants found at weaning decreases

skeleton
• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice
• variable abnormalities of the middle ear bones in some small mice
• coronal craniosynostosis at P5-15 in small mice only and not in small or normal sized wild-type mice

hearing/vestibular/ear
• variable abnormalities of the middle ear bones in some small mice
• variable abnormalities of the otic capsule in some small mice
• unilateral or bilateral elevation in auditory brainstem responses were seen in 3 of 3 small mice that survived to P21-28

craniofacial
• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice
• variable abnormalities of the middle ear bones in some small mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory