mortality/aging
• fewer than expected are found at weaning
• Background Sensitivity: with further crosses to C57BL/6 mice the number of mutants found at weaning decreases
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skeleton
• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice
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• variable abnormalities of the middle ear bones in some small mice
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• coronal craniosynostosis at P5-15 in small mice only and not in small or normal sized wild-type mice
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hearing/vestibular/ear
• variable abnormalities of the middle ear bones in some small mice
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• variable abnormalities of the otic capsule in some small mice
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• unilateral or bilateral elevation in auditory brainstem responses were seen in 3 of 3 small mice that survived to P21-28
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craniofacial
• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice
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• variable abnormalities of the middle ear bones in some small mice
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