Phenotypes Associated with This Genotype

Genotype
MGI:3696840

• Allelic Composition: Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:117494 , J:165667 )

• double mutants are observed at E18.5; a small number survive past birth (J:117494)

• Background Sensitivity: survival is extended compared to B6 congenic background (J:117494)

• fewer than expected mice are alive at birth (J:165667)

postnatal lethality, incomplete penetrance ( J:165667 )

• very few mice are present at weaning

growth/size/body

fetal growth retardation ( J:117494 )

• at E18.5, animals are markedly smaller than control littermates

digestive/alimentary system

abnormal digestive system development ( J:117494 )

• mice surviving to P2 show abnormal development of digestive system; milk spot appears diffuse and spread out over entire abdomen