Phenotypes Associated with This Genotype

Genotype
MGI:3696823

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:165667 )

• mice die sooner than Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

neoplasm

increased mammary gland tumor incidence ( J:165667 )

• after 12 months of age compared with Mcm3^{Gt(RRR002)Byg}/ Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

increased lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

increased T cell derived lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

hematopoietic system

abnormal erythrocyte morphology ( J:117494 , J:165667 )

• >7% of erythrocytes contain micronuclei (J:117494)

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice (J:165667)

cellular

abnormal cell nucleus morphology ( J:117494 )

• show 20-fold elevated micronucleus frequencies compared to wild-type

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

integument

increased mammary gland tumor incidence ( J:165667 )

• after 12 months of age compared with Mcm3^{Gt(RRR002)Byg}/ Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:165667 )

• after 12 months of age compared with Mcm3^{Gt(RRR002)Byg}/ Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice

increased T cell derived lymphoma incidence ( J:165667 )

• unlike Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 mice