Phenotypes Associated with This Genotype

Genotype
MGI:3696695

• Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell death ( J:117113 )

• after adenoviral cre infection, OSE cells in culture show significantly higher sensitivity to cisplatin treatment compared to control cells (47.3% remain ater 48 hours compared to 66.2% of control cells remaining)

decreased cell proliferation ( J:117113 )

• cultured cre-infected ovarian surface epithelium (OSE) cells show slower growth than GFP-injected cells at 96 and 120 hours post injection; at 120 hours, cell numbers are decreased by 40% compared to controls

endocrine/exocrine glands

abnormal ovary morphology ( J:117113 )

♀ • after adenoviral-cre-mediated recombination in the ovarian surface epithelium, significantly greater morphological changes are observed compared to controls receiving adenoviral GFP injection

♀ • there a 4-fold more epithelial invaginations in cre-injected ovaries than in GFP-injected controls at 240 days post-injection

reproductive system

abnormal ovary morphology ( J:117113 )

♀ • after adenoviral-cre-mediated recombination in the ovarian surface epithelium, significantly greater morphological changes are observed compared to controls receiving adenoviral GFP injection

♀ • there a 4-fold more epithelial invaginations in cre-injected ovaries than in GFP-injected controls at 240 days post-injection