Mouse Genome Informatics
tg
    Tg(APP695)3Dbo/0
B6.C3-Tg(APP695)3Dbo
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

behavior/neurological
• at 24 months, males display a mild deterioration of sensorimotor abilities
• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task

homeostasis/metabolism
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 4 606889 J:109847
Alzheimer Disease; AD 104300 J:109847