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Phenotypes Associated with This Genotype
Genotype
MGI:3696575
Allelic
Composition
Tg(APP695)3Dbo/0
Genetic
Background
B6.C3-Tg(APP695)3Dbo
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

behavior/neurological
• at 24 months, males display a mild deterioration of sensorimotor abilities
• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task

homeostasis/metabolism
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 4 606889 J:109847
Alzheimer Disease; AD 104300 J:109847


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory