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Phenotypes Associated with This Genotype
Genotype
MGI:3695904
Allelic
Composition
Lepob/Lepob
Ppargtm1Avp/Pparg+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (6 available); any Lep mutation (19 available)
Ppargtm1Avp mutation (1 available); any Pparg mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased compared to mice that are wild-type at the Lep locus and on a high fat diet
• increased at 4 weeks of age in fed mice relative to Lepob homozygotes and wild-type mice
• not significantly different from Lepob homozygotes, but increased compared to wild-type mice
• increased relative to Lepob homozygotes
• reduced adiponectin level, independent of presence or absence of the Lepob allele

growth/size/body
• at 12 weeks of age fat mass is reduced relative to Lepob homozygotes
• at 5 weeks of age body mass is decreased relative to Lepob homozygotes, but is still higher than in wild-type mice
• at 12 weeks of age body mass is reduced by 14% and 12 % in females and males, respectively, relative to Lepob homozygotes

adipose tissue
• reduced amount of gonadal and subcutaneous white fat relative to Lepob homozygotes
• at 12 weeks of age fat mass is reduced relative to Lepob homozygotes
• smaller adipocytes in the gonadal and subcutaneous white fat relative to Lepob homozygotes
• reduced amount relative to Lepob homozygotes

liver/biliary system
• at 12 weeks of age relative to Lepob homozygotes
• at 12 weeks of age relative to Lepob homozygotes

muscle
• reduced intramyocellular lipid deposition relative to Lepob homozygotes

behavior/neurological
• not significantly different from Lepob homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory