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Phenotypes Associated with This Genotype
Genotype
MGI:3695740
Allelic
Composition
Ctsktm1Psa/Ctsktm1Psa
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1Psa mutation (1 available); any Ctsk mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Radiographs and histological analysis of Ctsktm1Psa/Ctsktm1Psa mice

skeleton
• resorptive bone surfaces poorly defined with a broad fringe of demineralized matrix
• osteoclasts seeded onto dentine sections develop shallower pits with thicker layers of unprocessed residual matrix
• diaphyseal cortical bone is less readily distinguished from subjacent trabecular bone
• increased height of tibial growth plates
• external form of bones is more gracile
• dense trabeculation of bone marrow spaces in long bones particularly in regions of rapid longitudinal growth, distal femur and proximal tibia
• retention of cancellous bone in the shafts of long bones
• primary spongiosa of vertebrae is retained as well
• plates of bone more common than in controls where thinner rods are more typical

respiratory system
• 1.5X greater collagen concentrations than in controls
• untreated mice with 20% thicker alveolar walls
• more pronounced alveolar wall remodeling after bleomycin administration, increased 18% as opposed to 6% in controls
• collagen concentration increased 3 fold as opposed to 2 fold in controls

immune system
• resorptive bone surfaces poorly defined with a broad fringe of demineralized matrix
• osteoclasts seeded onto dentine sections develop shallower pits with thicker layers of unprocessed residual matrix

hematopoietic system
• resorptive bone surfaces poorly defined with a broad fringe of demineralized matrix
• osteoclasts seeded onto dentine sections develop shallower pits with thicker layers of unprocessed residual matrix

homeostasis/metabolism
• significantly larger amounts of amyloid deposited in the spleen
• amyloid deposits of smaller sized protein


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory