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Phenotypes Associated with This Genotype
Genotype
MGI:3695719
Allelic
Composition
Krt4Bcc1/Krt4Bcc1
Genetic
Background
C3HeB/FeJ-Krt4Bcc1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt4Bcc1 mutation (0 available); any Krt4 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slight but significant reduction in survival

craniofacial
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

digestive/alimentary system
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

growth/size/body
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable
• runted and underdeveloped by 2 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
White Sponge Nevus 1; WSN1 193900 J:116740


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory