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Phenotypes Associated with This Genotype
Genotype
MGI:3695719
Allelic
Composition
Krt4Bcc1/Krt4Bcc1
Genetic
Background
C3HeB/FeJ-Krt4Bcc1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slight but significant reduction in survival

craniofacial
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

digestive/alimentary system
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable

growth/size/body
• mild lymphocytic infiltration in the submucosa
• primarily on the tongue but also found on the palatal and esophageal mucosa
• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact
• normal architecture is absent and the tissue is friable
• runted and underdeveloped by 2 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary mucosal leukokeratosis DOID:0050448 OMIM:193900
OMIM:615785
J:116740


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory