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Phenotypes Associated with This Genotype
Genotype
MGI:3695432
Allelic
Composition		 Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (62 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:116130 )
• average tumor-free survival is 38 weeks

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:116130 )
• 6 of 10 mice develop pancreatic ductal adenocarcinoma

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:116130 )
• 6 of 10 mice develop pancreatic ductal adenocarcinoma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory