Phenotypes Associated with This Genotype

Genotype
MGI:3695273

• Allelic Composition: Cdh1^tm1Jjon/Cdh1⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:116152 )

• mice show longer tumor latency periods (330 days) compared to double conditional knockouts (214 days)

• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands

• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology

increased skin tumor incidence ( J:116152 )

• small numbers of skin carcinomas develop with latency of 330 days develop

• may be classified as pilomatriculomas or squamous cell carcinomas, without metastasis

increased pilomatricoma incidence ( J:116152 )

increased squamous cell carcinoma incidence ( J:116152 )

integument

increased mammary adenocarcinoma incidence ( J:116152 )

• mice show longer tumor latency periods (330 days) compared to double conditional knockouts (214 days)

• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands

• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology

increased skin tumor incidence ( J:116152 )

• small numbers of skin carcinomas develop with latency of 330 days develop

• may be classified as pilomatriculomas or squamous cell carcinomas, without metastasis

increased pilomatricoma incidence ( J:116152 )

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:116152 )

• mice show longer tumor latency periods (330 days) compared to double conditional knockouts (214 days)

• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands

• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology