Phenotypes Associated with This Genotype

Genotype
MGI:3695271

• Allelic Composition: Cdh1^tm1Jjon/Cdh1^tm1Jjon; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor vascularization ( J:116152 )

• mammary tumors show large numbers of uniformly distributed blood vessels

• a 3-fold increase in vasculature is observed compared to mutants homozygous for Cdh1 deletion and heterozygous for Trp53 deletion

increased mammary adenocarcinoma incidence ( J:116152 )

• develop at accelerated rate compared to single conditional Trp53 mutant females

• multiple tumors develop with median latency of 214 days

• shift towards invasive from expansive carcinoma is observed with tumors classified as invasive lobulocarcinoma (ILC) developing multifocally in several mammary glands

• carcinosarcomas (having elements of carcinoma and sarcoma) develop, having spindle shaped cell morphology with large cells with pleomorphic nuclei; these display both expansive and invasive growth

increased skin tumor incidence ( J:116152 )

• develop at accelerated rate compared to single conditional Trp53 mutant females

• multiple tumors develop with median latency of 214 days

• often show phenotypic change from expansive to invasive growth

• tumors may invade subcutaneous fat or carnous muscle in irregular strands and nest with polymorphic cell with dyskeratosis

increased metastatic potential ( J:116152 )

• in females presenting carcinomas ~1 cm in diameter, majority of tumors show extensive local invasion with ~50% demonstrating metastasis to draining and distant lymph nodes

• minority of animals show dissociated or loosely clustered lobulocarcinoma (ILC) cells in lungs, liver, gastrointestinal and urogenital tracts, and pancreas, or diffusely throughout peritoneal cavity

cardiovascular system

abnormal tumor vascularization ( J:116152 )

• mammary tumors show large numbers of uniformly distributed blood vessels

• a 3-fold increase in vasculature is observed compared to mutants homozygous for Cdh1 deletion and heterozygous for Trp53 deletion

integument

increased mammary adenocarcinoma incidence ( J:116152 )

• develop at accelerated rate compared to single conditional Trp53 mutant females

• multiple tumors develop with median latency of 214 days

• shift towards invasive from expansive carcinoma is observed with tumors classified as invasive lobulocarcinoma (ILC) developing multifocally in several mammary glands

• carcinosarcomas (having elements of carcinoma and sarcoma) develop, having spindle shaped cell morphology with large cells with pleomorphic nuclei; these display both expansive and invasive growth

increased skin tumor incidence ( J:116152 )

• develop at accelerated rate compared to single conditional Trp53 mutant females

• multiple tumors develop with median latency of 214 days

• often show phenotypic change from expansive to invasive growth

• tumors may invade subcutaneous fat or carnous muscle in irregular strands and nest with polymorphic cell with dyskeratosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:116152 )

• develop at accelerated rate compared to single conditional Trp53 mutant females

• multiple tumors develop with median latency of 214 days

• shift towards invasive from expansive carcinoma is observed with tumors classified as invasive lobulocarcinoma (ILC) developing multifocally in several mammary glands

• carcinosarcomas (having elements of carcinoma and sarcoma) develop, having spindle shaped cell morphology with large cells with pleomorphic nuclei; these display both expansive and invasive growth