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Phenotypes Associated with This Genotype
Genotype
MGI:3695166
Allelic
Composition
Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

vision/eye
• precursors normally fated to become amacrine and horizontal cells switch to ganglion cell fates
• although cells belonging to the outer neuroblastic layer are confined to the ventricular zone in wild-type, they tend to invade into the ganglion cell layer in mutant retinas
• retinal explants are significantly thinner after 2 weeks of culture compared to wild-type and often exhibit substantial focal perturbations in laminar organization and rosette-like structures, however exhibit normal generation of photoreceptor cells, bipolar cells, and glial cells
• retinas at E16.5 show abnormal laminar organization
• lack of calbindin-positive and syntaxin-positive cells in cultured retinas indicates that amacrine cells, including the displaced amacrine cells in the ganglion cell layer, are profoundly missing
• increased number and expanded spatial localization of cells expressing the ganglion cell marker Brn3b in retinas indicating increased ganglion cell number
• precursors normally fated to become amacrine and horizontal cells switch to ganglion cell fates
• calbindin-positive cells in the outer border of the inner nuclear layer are entirely absent in cultured retinas, indicating complete loss of horizontal cells
• the ganglion cell layer is significantly thicker
• by E18.5, the inner plexiform layer is absent
• reduced expression of horizontal cell (HC) marker Lim1 at age E14.5

nervous system
• lack of calbindin-positive and syntaxin-positive cells in cultured retinas indicates that amacrine cells, including the displaced amacrine cells in the ganglion cell layer, are profoundly missing
• increased number and expanded spatial localization of cells expressing the ganglion cell marker Brn3b in retinas indicating increased ganglion cell number
• precursors normally fated to become amacrine and horizontal cells switch to ganglion cell fates
• calbindin-positive cells in the outer border of the inner nuclear layer are entirely absent in cultured retinas, indicating complete loss of horizontal cells

endocrine/exocrine glands
• neonates have no pancreas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory