Phenotypes Associated with This Genotype

Genotype
MGI:3694361

• Allelic Composition: Ube3a^tm1Alb/Ube3a^tm1Alb
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:50811 )

• Background Sensitivity: substantial reduction in postnatal survival compared to mice on 129/B6 background, is seen, with death frequently observed during the first 48 hours postnatal (about 80%)

growth/size/body

postnatal growth retardation ( J:50811 )

• surviving mice are often growth-retarded

behavior/neurological

limb grasping ( J:50811 )

• mice demonstrate hindlimb clasping when lifted by tail

abnormal posture ( J:50811 )

• mice often exhibit stationary posture when lifted by tail

bradykinesia ( J:50811 )

• surviving mice are less active than littermates

audiogenic seizures ( J:50811 )

• Background Sensitivity: observed in all mice (5/5)

• mice with maternal deficiency are susceptible to audiogenic seizures characterized by running and leaping followed by tonic clonic seizure

nervous system

audiogenic seizures ( J:50811 )

• Background Sensitivity: observed in all mice (5/5)

• mice with maternal deficiency are susceptible to audiogenic seizures characterized by running and leaping followed by tonic clonic seizure