Analysis Tools
mortality/aging
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• Background Sensitivity: slight reduction in survival prior to weaning compared to wild-type
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behavior/neurological
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• Background Sensitivity: observed in 20-30% of mice with maternal deficiency
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nervous system
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• Background Sensitivity: observed in 20-30% of mice with maternal deficiency
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reproductive system
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• oocyte numbers are~68% less in 3 week old homozygous females treated with PMSG and hCG
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• epididymal sperm counts are ~38% lower than in wild-type males
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• mammary gland development in ovarectomized females treated with progesterone and estradiol to mimic pregnance was comparable to wild-type at 12 and 14 weeks
• some females show increased ductal branching and lobuloalveolar development compared to wild-type controls, but penetrance of this phenotype is not consistent
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• prostate gland weight is lower in castrated mutants treated with testosterone, compared to control castrated males treated with testosterone
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• ovaries from 3-week old females treated with PMSG and hCG have fewer developing follicles
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• at 8-10 weeks of age, ovaries weigh ~30% less than wild-type ovaries; at later time points, difference is not observed
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• in 12 week old mice, testis weight is reduced by ~24% compared to wild-type
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• uterine wet weight is ~35% lower in mutant ovarectomized females after estradiol treament compared to matched controls
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• sperm has lower ability to penetrate oocytes in vitro compared to controls
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• ovaries from 3-week old females treated with PMSG and hCG are relatively deficient in luteinized cells
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• female are subfertile
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• litters sired by homozygous males with wild-type females have ~34% fewer pups/litter
• litter size is ~48% lower in homozygous females compared to wild-type
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• total number of offspring sired by homozygous males with wild-type females is reduced compared to wild-type males
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endocrine/exocrine glands
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• mammary gland development in ovarectomized females treated with progesterone and estradiol to mimic pregnance was comparable to wild-type at 12 and 14 weeks
• some females show increased ductal branching and lobuloalveolar development compared to wild-type controls, but penetrance of this phenotype is not consistent
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• prostate gland weight is lower in castrated mutants treated with testosterone, compared to control castrated males treated with testosterone
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• ovaries from 3-week old females treated with PMSG and hCG have fewer developing follicles
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• at 8-10 weeks of age, ovaries weigh ~30% less than wild-type ovaries; at later time points, difference is not observed
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• in 12 week old mice, testis weight is reduced by ~24% compared to wild-type
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integument
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• mammary gland development in ovarectomized females treated with progesterone and estradiol to mimic pregnance was comparable to wild-type at 12 and 14 weeks
• some females show increased ductal branching and lobuloalveolar development compared to wild-type controls, but penetrance of this phenotype is not consistent
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cellular
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• oocyte numbers are~68% less in 3 week old homozygous females treated with PMSG and hCG
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• epididymal sperm counts are ~38% lower than in wild-type males
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