Phenotypes Associated with This Genotype

Genotype
MGI:3694209

• Allelic Composition: Ddr2^tm1Kln/Ddr2^tm1Kln
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skull comparison of Ddr1^tm1Wfv/Ddr1^tm1Wfv, Ddr2^tm1Kln/Ddr2^tm1Kln and Ddr2^tm1Kln/Ddr2⁺ mice

growth/size/body

abnormal nasal bone morphology ( J:123719 )

• altered nasal bone

short snout ( J:74580 )

decreased body size ( J:74580 )

• obvious at 10 days of age

decreased body weight ( J:74580 )

disproportionate dwarf ( J:74580 )

postnatal growth retardation ( J:74580 )

• although normal at birth, homozygotes fail to thrive

cellular

decreased cell proliferation ( J:74580 )

• slow proliferation of skin fibroblasts

• reduced proliferation of epidermal keratinocytes during wound healing

• fewer proliferating cells in growth plates of bones

skeleton

abnormal cranium morphology ( J:123719 )

• spherical skull shape

decreased cranium height ( J:123719 )

• skulls are jolted as shown by a reduced length

small cranium ( J:74580 , J:123719 )

• skull length reduced up to 20% by 4 months of age (J:74580)

• irregular growth of flat bones (J:74580)

abnormal neurocranium morphology ( J:123719 )

• neurocranium shows a more round shape

abnormal nasal bone morphology ( J:123719 )

• altered nasal bone

decreased length of long bones ( J:74580 )

• shortened by 12-15% in length by 4 months of age

abnormal epiphyseal plate morphology ( J:74580 )

• growth plate height reduced 16% in metatarsals at 2 weeks of age

• chondrocyte apoptosis is normal

• marked reduction in the number of proliferating cells in the metatarsal growth plate, particularly at 2 weeks of age but also at 3 weeks

craniofacial

abnormal cranium morphology ( J:123719 )

• spherical skull shape

decreased cranium height ( J:123719 )

• skulls are jolted as shown by a reduced length

small cranium ( J:74580 , J:123719 )

• skull length reduced up to 20% by 4 months of age (J:74580)

• irregular growth of flat bones (J:74580)

abnormal neurocranium morphology ( J:123719 )

• neurocranium shows a more round shape

abnormal nasal bone morphology ( J:123719 )

• altered nasal bone

short snout ( J:74580 )

homeostasis/metabolism

delayed wound healing ( J:74580 )

• reduced proliferative response in epidermal keratinocytes during skin wound healing

respiratory system

abnormal nasal bone morphology ( J:123719 )

• altered nasal bone