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Phenotypes Associated with This Genotype
Genotype
MGI:3694084
Allelic
Composition		 Atp1a1tm1Ling/Atp1a1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle contractility ( J:114415 )
• peak tetanic force produced by extensor digitorum longus (EDL) muscle at supramaximal stimulation is ~240 mN/sq. mm compared to 297 mN/sq. mm in wild-type
• EDL muscle produces similar twitch force to wild-type muscle
• contractility of mutant muscle is increased with ouabain inhibition of Atp1a2
• constant for fatigue is similar to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory