Phenotypes for Lep MGI:3694010 MGI Mouse

increased pancreas weight ( J:107169 )

• 0.41 g vs 0.29 in wild-type

decreased lean body mass ( J:107169 )

• decreased (16.0 g, 33% of body weight) compared to wild-type (25.5 g 87% of body weight) or double mutants (19.8g)

increased body weight ( J:107169 )

• higher than wild-type

increased kidney weight ( J:107169 )

• 0.54 g vs 0.41 g in wild-type

increased liver weight ( J:107169 )

• 4.56 g vs 1.44 g in wild-type

hyperglycemia ( J:107169 )

abnormal circulating hormone level ( J:76479 )

decreased circulating testosterone level ( J:76479 , J:107169 )

• level is markedly decreased compared to wild-type or Lep heterozygotes (J:76479)

• significantly lower (4.2 nmol/l) compared to wild-type (14.2 nmol/l) (J:107169)

increased circulating corticosterone level ( J:76479 , J:107169 )

• mice display hypercorticosteronemia compared to wild-type (J:76479)

• mice display hypercorticosteronemia compared to wild-type, Npy2r^tm1.1Hhz homozygotes, or Npy2r, Lep double mutants (J:107169)

increased circulating insulin level ( J:76479 , J:107169 )

• level is significantly increased over wild-type (J:76479)

• hyperinsulinemic compared to wild-type (J:107169)

increased circulating leptin level ( J:76479 )

• level is significantly increased over wild-type

abnormal circulating pancreatic peptide level ( J:76479 )

• plasma levels of pancreatic polypeptide (PP) are strongly reduced compared to wild-type

increased circulating cholesterol level ( J:107169 )

• 5.74 mmol/l vs 3.54 mmol/l in wild-type

increased circulating triglyceride level ( J:107169 )

• 2.48 mmol/l vs 1.62 mmol/l in wild-type

abnormal branching of the mammary ductal tree ( J:76479 )

• in virgin females, no ductal development occurs

decreased seminal vesicle weight ( J:76479 )

• weight of gland is significantly lower than wild-type or heterozygotes

increased pancreas weight ( J:107169 )

• 0.41 g vs 0.29 in wild-type

absent corpus luteum ( J:76479 )

• no corpora lutea develops properly in ovary

decreased primary ovarian follicle number ( J:76479 )

• ovaries have very few primary follicles

decreased secondary ovarian follicle number ( J:76479 )

• ovaries have very few secondary follicles

decreased testis weight ( J:76479 , J:107169 )

• testis weight is significantly lower than in Lep^ob heterozygotes or Lep, Ppyr1 double null mice (J:76479)

• testes weigh 0.19 g compared to 0.33 g in wild-type (J:107169)

abnormal adipose tissue amount ( J:107169 )

• combined white adipose tissue (WAT) mass is increased compared to wild-type

decreased seminal vesicle weight ( J:76479 )

• weight of gland is significantly lower than wild-type or heterozygotes

absent corpus luteum ( J:76479 )

• no corpora lutea develops properly in ovary

decreased primary ovarian follicle number ( J:76479 )

• ovaries have very few primary follicles

decreased secondary ovarian follicle number ( J:76479 )

• ovaries have very few secondary follicles

decreased testis weight ( J:76479 , J:107169 )

• testis weight is significantly lower than in Lep^ob heterozygotes or Lep, Ppyr1 double null mice (J:76479)

• testes weigh 0.19 g compared to 0.33 g in wild-type (J:107169)

abnormal vagina orifice morphology ( J:76479 )

• vaginal opening is very small compared to wild-type

prolonged diestrus ( J:76479 )

• mice have diestrous-like swab until 9 weeks of age

prolonged estrus ( J:76479 )

• beginning at 9 weeks of age, estrous-like cytology lasts 6-8 days

prolonged estrous cycle ( J:76479 )

• beginning at 9 weeks of age, estrous cycles last 11-15 days

female infertility ( J:76479 )

• homozygous females produce no litters

male infertility ( J:76479 , J:107169 )

• only one male tested was able to sire a litter (J:76479)

• no males could produce offspring (J:107169)

polyphagia ( J:107169 )

abnormal intestine morphology ( J:107169 )

• mice display intestinal hypertrophy compared to wild-type mice (intestine weight - 1.89 g vs 1.03 g in wild-type; intestine length 43 cm vs 33 cm in wild-type)