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Phenotypes Associated with This Genotype
Genotype
MGI:3694008
Allelic
Composition
Lepob/Lepob
Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (19 available)
Npy4rtm1.1Hhz mutation (0 available); any Npy4r mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• male mutants gain significantly more weight than Lepob homozygous controls between 4 and 16 weeks

endocrine/exocrine glands
• in nulliparous females, no ductal development occurs, and gland remains in prepubescent state
• females having had one full-term pregnancy show varying degrees of mammary development; some females show minimal ductal elongation, while others show large areas of lobules with presence of milk
• females are incapable of ensuring survival of offspring due to defects in mammary gland structure and physiology
• gland is significantly increased in weight compared to Lepob homozygotes, and is comparable to wild-type
• large empty follicles characteristic of Lepob mice are present
• Leydig cell density is increased over Lepob homozygotes

homeostasis/metabolism
N
• insulin and leptin levels are not increased over Lepob homozygotes
• levels are significantly increased over levels found in Lepob homozygotes; levels are similar to wild-type
• hypercorticosteronemia is significantly attenuated compared to Lepob homozygotes

adipose tissue
• WAT amount is significantly higher than in control Lepob heterozygotes

reproductive system
• gland is significantly increased in weight compared to Lepob homozygotes, and is comparable to wild-type
• large empty follicles characteristic of Lepob mice are present
• Leydig cell density is increased over Lepob homozygotes
• in infertile females, vaginal orifice is small with cytology similar to Lepob homozygotes
• sperm density is increased over Lepob homozygotes
• all males tested produced offspring, while only 4/8 females produced live offspring compared to severely reduced fertility in Lepob homozygous male and female mice

integument
• in nulliparous females, no ductal development occurs, and gland remains in prepubescent state
• females having had one full-term pregnancy show varying degrees of mammary development; some females show minimal ductal elongation, while others show large areas of lobules with presence of milk
• females are incapable of ensuring survival of offspring due to defects in mammary gland structure and physiology


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory