Phenotypes Associated with This Genotype

Genotype
MGI:3693952

• Allelic Composition: Npy4r^tm1.1Hhz/Npy4r^tm1.1Hhz
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:76479 )

• 4-week old females weigh significantly less than controls

• males and females gain significantly less weight between 4 and 16 weeks of age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:76479 )

N • levels of leptin, insulin, and glucose do not differ from wild-type

N • testosterone tends to be lower in mutants but this does not become significant

abnormal circulating pancreatic peptide level ( J:76479 )

♂ • males exhibit 2- to 3-fold higher plasma levels of pancreatic polypeptide (PP)

behavior/neurological

increased fluid intake ( J:115774 )

• mutants drink more water during the dark phase, but this is only significant on the second and third days of the 3 day observation period

• daily water intake is elevated only on second and third day compared to controls

• this behavior is maintained following injection of physiological saline (vehicle). beta-adrenoreceptor antagonist propanolol, or angiotensin AT1 receptor antagonist telmisartan

abnormal food intake ( J:76479 )

• males have lower food intake/24 hours than wild-type controls

increased aggression towards mice ( J:76479 )

• male mutants show very aggressive behavior, with instances of fighting between littermates causing injuries

• female mutants become aggressive toward littermates after 20-24 weeks of age

adipose tissue

decreased white adipose tissue amount ( J:76479 )

• male mice have a significantly lower mass of white adipose tissue (WAT) compared to controls

abnormal fat pad morphology ( J:76479 )

• mesenteric WAT is major contributor to reduced WAT mass (0.65 % of body weight in male mutant vs 0.84% in male wild-type and 0.53% in female mutant vs 0.76% in female wild-type)

reproductive system

abnormal mammary gland growth during pregnancy ( J:76479 )

♀ • lobuloalveolar development is accelerated compared to wild-type (lobuloalveolar content on day 16 is 18.74% area of 4th gland compared to 15.79% in wild-type)

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:76479 )

♀ • lobuloalveolar development is accelerated compared to wild-type (lobuloalveolar content on day 16 is 18.74% area of 4th gland compared to 15.79% in wild-type)

integument

abnormal mammary gland growth during pregnancy ( J:76479 )

♀ • lobuloalveolar development is accelerated compared to wild-type (lobuloalveolar content on day 16 is 18.74% area of 4th gland compared to 15.79% in wild-type)