Analysis Tools
mortality/aging
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• mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls
• treatment with exogenous IFNG improves survival
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• more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die
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immune system
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• in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice
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• following infection with type A influenza
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• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells
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• T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells
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• the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls
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• following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells
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• the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls
(J:29170)
• display an increased IgG1 antibody response to type A influenza infection
(J:110721)
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• at 14 days after infection with virulent Mycobacterium tuberculosis, 10- 100 fold more viable bacteria are found in the organs compared to organs of wild-type controls
• at 14 days after infection with virulent Mycobacterium tuberculosis, about 90% of the granulomas in the liver and 20% of the granulomas in the spleen are necrotic
• treatment with exogenous IFNG decreases the bacterial load
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• mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls
• treatment with exogenous IFNG improves survival
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• at 5 - 8 days post infection mice develop more severe conjunctivitis, periocular skin lesions, corneal opacity, and anterior chamber exudate following infection with HSV-1 relative to wld-type BALB/c controls infected with a higher dose of virus
• infectious virus is detected up to 10 days post infection with HSV-1 in mutants compared to up to 4 or days post infection in wild-type BAL/c mice or littermate controls, respectively
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• more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die
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vision/eye
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• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
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homeostasis/metabolism
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• T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells
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cardiovascular system
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• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
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hematopoietic system
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• in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice
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• following infection with type A influenza
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• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells
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