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Phenotypes Associated with This Genotype
Genotype
MGI:3693287
Allelic
Composition
Zfp423nur12/Zfp423nur12
Genetic
Background
involves: BALB/c * C57BL/6 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp423nur12 mutation (4 available); any Zfp423 mutation (233 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ataxia and malformation in Zfp423nur12/Zfp423nur12 mice

behavior/neurological

nervous system
• reduced choroids plexus of the 4th ventricle
• reduced hippocampal formations
• malformed
• pronounced anterior rotation of the cerebellum in the posterior fossa
• decreased cell proliferation in the germinal zones of the cerebellum
• Bergman glia fail to infiltrate the cerebellar cortex
• radial glial fibers found at lower densities than in controls
• evident by E15.5

growth/size/body
• P14 mutants show reduced weight gain

Mouse Models of Human Disease
OMIM ID Ref(s)
Dandy-Walker Syndrome; DWS 220200 J:114758


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory