About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3692774
Allelic
Composition
Tbx5tm1Jse/Tbx5+
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx5tm1Jse mutation (0 available); any Tbx5 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 27% die prior to weaning

cardiovascular system
• all mice exhibit atrial septal defects; atrial septal defects are smaller than in Tbx5tm1.1Jse heterozygotes
• however, mice do not have ventricular septal defects
• all show an enlargement of the atria
• cardiac monitoring over 48 hours shows sporadic electrophysiological anomalies, including occurrences of ventricular tachycardia, sinus rhythm with atrial complexes, secondary degree AV block and sinoatrial pauses
• occurrences of sinus rhythm anomalies with atrial complexes
• occurrences of ventricular tachycardia
• increase in PQ-interval duration at 12 weeks of age, indicative of first degree atrioventricular block; block is less severe than that seen in Tbx5tm1.1Jse heterozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Holt-Oram syndrome DOID:0060468 OMIM:142900
J:112887


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory