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Phenotypes Associated with This Genotype
Genotype
MGI:3692743
Allelic
Composition
Gfaptm3Mes/Gfap+
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm3Mes mutation (1 available); any Gfap mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

nervous system
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit fewer Rosenthal fibers than seen in heterozygous Gfaptm2Hgmn mutants

Mouse Models of Human Disease
OMIM ID Ref(s)
Alexander Disease; ALXDRD 203450 J:114689


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory