Phenotypes for Gfap MGI:3692743 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gfap^tm3Mes/Gfap⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfap^tm3Mes mutation (1 available); any Gfap mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:114689 )

nervous system

abnormal astrocyte morphology ( J:114689 )

• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions

• exhibit fewer Rosenthal fibers than seen in heterozygous Gfap^tm2Hgmn mutants

gliosis ( J:114689 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alexander disease		DOID:4252	OMIM:203450	J:114689

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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