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Phenotypes Associated with This Genotype
Genotype
MGI:3691621
Allelic
Composition
Casq2tm1Klmn/Casq2tm1Klmn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casq2tm1Klmn mutation (0 available); any Casq2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Junctional sarcoplasmic reticulum lacks its visible content, and overall sarcoplasmic reticulum volume is increased in ventricular myocytes of Casq2tm1Klmn/Casq2tm1Klmn mice

cardiovascular system
• approximately 10% increase in heart to body weight ratio (J:114621)
• approximately 10% increase in heart to body weight ratio (J:114621)
• modest but statistically significant increase in ventricular wall thickness (J:114621)
• modest but statistically significant increase in ventricular wall thickness (J:114621)
• display a significantly slower heart rate but normal cardiac contractility, normal left-ventricular cavity size, and unchanged ECG parameters (J:114621)
• homozygous mice were viable and fertile (J:114621)
• display a significantly slower heart rate but normal cardiac contractility, normal left-ventricular cavity size, and unchanged ECG parameters (J:114621)
• homozygous mice were viable and fertile (J:114621)
• exposure to catecholamine in homozygous mice myocytes caused polymorphic nonsustained ventricular tachycardia, a phenocopy of the human arrhythmias (J:114621)
• exposure to catecholamine in homozygous mice myocytes caused polymorphic nonsustained ventricular tachycardia, a phenocopy of the human arrhythmias (J:114621)
• exhibited striking increases in sarcoplasmic reticulum volume and surface area (J:114621)
• exposure to catecholamines caused increased diastolic sarcoplasmic reticulum Ca2+ leak (J:114621)
• exhibited striking increases in sarcoplasmic reticulum volume and surface area (J:114621)
• exposure to catecholamines caused increased diastolic sarcoplasmic reticulum Ca2+ leak (J:114621)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory