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Phenotypes Associated with This Genotype
Genotype
MGI:3691280
Allelic
Composition
Myh6tm1Ces/Myh6tm1Ces
Genetic
Background
involves: 129S/SvEv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh6tm1Ces mutation (0 available); any Myh6 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• progress rapidly to dilated cardiomyopathy, however do not exhibit myofibrillar disarray or fibrosis
• develop contractile dysfunction and reduced fractional shortening at around 12 weeks of age

muscle
• progress rapidly to dilated cardiomyopathy, however do not exhibit myofibrillar disarray or fibrosis
• develop contractile dysfunction and reduced fractional shortening at around 12 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:114549


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory