digestive/alimentary system
• forestomach epithelial thickness is significantly greater than wild-type
• forestomach shows marked exophytic papillary folding with massive production of laminated cornified cells on lumenal surface
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• infiltrates of inflammatory cells in lamina propria causes separation of gastric pits and formation of nest-like glandular structures
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• forestomach is significantly thicker (200 um) than controls (37 um)
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• consists of tortuous gastric pits with many short columnar cells with basilar nuclei
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• mild to moderate mixed inflammatory infiltrates are found in lamina propria throughout stomach
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hematopoietic system
immune system
• mild to moderate mixed inflammatory infiltrates are found in lamina propria throughout stomach
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neoplasm
• mice develop gastric papillomas, with greater frequency than controls
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