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Phenotypes Associated with This Genotype
Genotype
MGI:3690629
Allelic
Composition
Ttc7fsn/Ttc7fsn
Genetic
Background
involves: A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttc7fsn mutation (1 available); any Ttc7 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• forestomach epithelial thickness is significantly greater than wild-type
• forestomach shows marked exophytic papillary folding with massive production of laminated cornified cells on lumenal surface
• infiltrates of inflammatory cells in lamina propria causes separation of gastric pits and formation of nest-like glandular structures
• forestomach is significantly thicker (200 um) than controls (37 um)
• consists of tortuous gastric pits with many short columnar cells with basilar nuclei
• mild to moderate mixed inflammatory infiltrates are found in lamina propria throughout stomach

hematopoietic system
• packed cell volumes (PCVs) are 22.6 compared to ~45 for controls

immune system
• mild to moderate mixed inflammatory infiltrates are found in lamina propria throughout stomach

neoplasm
• mice develop gastric papillomas, with greater frequency than controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory