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Phenotypes Associated with This Genotype
Genotype
MGI:3690223
Allelic
Composition
Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic
Background
B6.129S2-Serpine1tm1Mlg/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpine1tm1Mlg mutation (4 available); any Serpine1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• aortic vessel explants show increased capillary sprouting in both collagen lattices and Matrigel
• older mutants develop cardiac fibrosis, however fibrosis is not seen in the liver, spleen, lungs or kidneys and do not develop small vessel disease
• SARS-CoV MA15-infected mice show increased lung hemorrhage at 7 dpi
• older mutants exhibit significantly more macrophages in the heart

respiratory system
• SARS-CoV MA15-infected mice show increased lung hemorrhage at 7 dpi

immune system
• older mutants exhibit significantly more macrophages in the heart
• following infection with live Streptococcus pneumoniae, S. pneumoniae wild-type lysate, and S. pneumoniae pneumolysin (PLY), mice begin to die earlier and are all dead by 5 days post-infection
• following infection with S. pneumoniae, acute lung injury and alveolar hemorrhage is enhanced
• following infection with S. pneumoniae strain ATCC 6303 (a more virulent strain), mortality is increased (10% survival compared to 45% in wild-type mice)
• mice infected with a sublethal dose of mouse-adapted SARS-CoV MA15 continue to lose weight through day 7 postinfection, showing more weight loss than wild-type controls at 5-7 days post infection (dpi), decreased locomotion, hunched posture, and labored breathing
• SARS-CoV MA15-infected mice exhibit cuffing of inflammatory cells around the large airways and vasculature and mild interstitial membrane thickening and a few inflammatory cells in the alveolar spaces at 4 dpi, with moderate level of disease in the parenchyma by 7 dpi
• however, virus load of SARS-CoV MA15-infected mice is similar to wild-type controls
• mice infected with a lethal dose of SARS-CoV MA15 succumb to infection sooner than wild-type controls

homeostasis/metabolism
• 3 weeks after BDL, urokinase plasminogen activator (uPA) and plasmin activity are not increased in mutants but tissue-type plasminogen activator (tPA) activity is significantly increased relative to wild-type
• 3 weeks after BDL, pro-MMP-9 and MMP-9 activities in liver homogenates from mutants are increased significantly compared to wild-type controls

liver/biliary system
N
• stellate cell activation, TGFbeta-1 and collagen synthesis are similar in mutants and controls before and after bile duct ligation
• 3 weeks after bile duct ligation (BDL), hepatic fibrosis is reduced 18-26% compared to wild-type; hepatic collagen content is similar to sham-operated wild-type

mortality/aging
• mice infected with a lethal dose of SARS-CoV MA15 succumb to infection sooner than wild-type controls
• following infection with live Streptococcus pneumoniae, S. pneumoniae wild-type lysate, and S. pneumoniae pneumolysin (PLY), mice begin to die earlier and are all dead by 5 days post-infection
• following infection with S. pneumoniae strain ATCC 6303 (a more virulent strain), mortality is increased (10% survival compared to 45% in wild-type mice)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:288556


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/21/2021
MGI 6.17
The Jackson Laboratory