Analysis Tools
immune system
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• there were no dectectable levels of IgE in 5 of 6 mice compared to controls, which all had dectectable levels
• after infection with a nematode, 6-week old animals have almost undetectable IgE levels compared to controls which show about 50-fold increase in levels after infection
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• homozygotes have about 1/6 the level of IgG1 of wild-type at 6 weeks
• in response to immunization with chicken globulin, antibodies produced by mutants are ~40-50% IgG1, while wild-type mice produce >95% IgG1-specific antibodies
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• conA stimulated spleen cells from homozygotes secrete ~800-fold less Il4 than control cells
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• upon infection with Schistosoma mansoni eggs, primary granuloma formation and volume is equivalent to wild-type
• volumes of secondary granulomas after second exposure with parasite eggs are reduced by ~50% compared to wild-type
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hematopoietic system
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• there were no dectectable levels of IgE in 5 of 6 mice compared to controls, which all had dectectable levels
• after infection with a nematode, 6-week old animals have almost undetectable IgE levels compared to controls which show about 50-fold increase in levels after infection
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• homozygotes have about 1/6 the level of IgG1 of wild-type at 6 weeks
• in response to immunization with chicken globulin, antibodies produced by mutants are ~40-50% IgG1, while wild-type mice produce >95% IgG1-specific antibodies
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