Mouse Genome Informatics
hm
    Leprdb/Leprdb
B6.Cg-Dock7m +/+ Leprdb/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• increase in body weight becomes apparent at 4-6 weeks of age (J:18161)
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age (J:82334)
• body weight is 10% and 20% more in males and females, respectively, compared to Leprrtm1Mgmj homozygotes (J:82334)
• develop progressive obesity (J:103063)
• snout to anus length is decreased by about 5% compared to wild-type mice

behavior/neurological

cardiovascular system
• exhibit myocyte hypertrophy
• increase in left ventricle wall thickness and mass is seen by 6 months of age but not at 2 months of age
• induced weight loss via leptin infusion, but not via caloric restriction, partially resolves the hypertrophy

muscle
• exhibit myocyte hypertrophy

homeostasis/metabolism
• HDL cholesterol and glucose levels increase concurrently
• Background Sensitivity: plasma lipid levels are similar at 3.5 and 14 months of age on the C57BL/6J background unlike on a C57BL/KsJ background
• fasting plasma total cholesterol concentration is increased 2 fold over controls
• triglyceride levels are elevated 1.5- to 2-fold (J:18161)
• female mice exhibit an increase in hypothalamic gonadotrophin releasing hormone compared to in wild-type mice
• decreased in serum
• elevated levels of eotaxin, keratinocyte cytokine, and monocyte chemotactic protein-1 (also elevated in serum) in bronchoalveolar lavage fluid
• elevated levels of IL-6 in bronchoalveolar lavage fluid
• elevated levels of IL-6 in serum

reproductive system
• atrophy of the reproductive organs (J:82334)
(J:6157)
(J:82334)
• females never show signs of vaginal oestrous (J:82334)
• mice exhibit diestrous vaginal acyclicity or occasional metestrous acyclicity (J:6157)
(J:6157)
• all females fail to reproduce (J:82334)

respiratory system
• elevated levels of eotaxin, Il6, keratinocyte cytokine, monocyte chemotactic protein-1, and neutrophiles in bronchoalveolar lavage as a result of ozone exposure
• ozone induces significantly elevated levels of TNFR1
• ozone induces a nonsignificant elevation of TNFR2 levels
• elevated pulmonary levels of Il1beta mRNA 24 hours after ozone exposure
• elevated pulmonary levels of TNF mRNA 24 hours after ozone exposure but to a lesser extent than in controls
• reduced
• pressure volume curves shifted to the right
• end-expiratory pause increases considerably less than in controls after ozone exposure
• total lung resistance increases much more in response to ozone than in control mice
• responsiveness to methacholine and serotonin is much greater than controls
• ventilation volumes decline with ozone exposure but to a lesser degree than for controls

immune system
• increased numbers in bronchoalveolar lavage
• decrease blood leukocyte numbers
• elevated levels of eotaxin, keratinocyte cytokine, and monocyte chemotactic protein-1 (also elevated in serum) in bronchoalveolar lavage fluid
• elevated levels of IL-6 in bronchoalveolar lavage fluid
• elevated levels of IL-6 in serum
• elevated pulmonary levels of TNF mRNA 24 hours after ozone exposure but to a lesser extent than in controls
• elevated levels of eotaxin, Il6, keratinocyte cytokine, monocyte chemotactic protein-1, and neutrophiles in bronchoalveolar lavage as a result of ozone exposure
• ozone induces significantly elevated levels of TNFR1
• ozone induces a nonsignificant elevation of TNFR2 levels
• elevated pulmonary levels of Il1beta mRNA 24 hours after ozone exposure

tumorigenesis
• increased metastasis to the lung of both melanoma cell lines and lung cancer cell lines initially injected in the tail vein

hematopoietic system
• increased numbers in bronchoalveolar lavage
• decrease blood leukocyte numbers

nervous system

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:18161 , J:82234 , J:103063