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Phenotypes Associated with This Genotype
Genotype
MGI:3689380
Allelic
Composition
Cftrtm2Mrc/Cftrtm2Mrc
Genetic
Background
B6.129S6-Cftrtm2Mrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm2Mrc mutation (0 available); any Cftr mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• able to eat a solid diet without developing intestinal blockage

growth/size/body
• did not differ significantly from wild-type controls at 7 days of age (P 0.05) but weighed significantly less than controls at 21 days of age

hematopoietic system
• lower relative neutrophil numbers
• greater absolute alveolar macrophage numbers

immune system
• lower relative neutrophil numbers
• greater absolute alveolar macrophage numbers
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

mortality/aging
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

respiratory system
• greater absolute alveolar macrophage numbers
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• after treatment with a chloride-depleted solution with amiloride and forskolin, the nasal potential difference (PD) was significantly different between control mice and homozygous mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cystic fibrosis DOID:1485 OMIM:219700
J:112450


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory