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Phenotypes Associated with This Genotype
Genotype
MGI:3689380
Allelic
Composition
Cftrtm2Mrc/Cftrtm2Mrc
Genetic
Background
B6.129S6-Cftrtm2Mrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm2Mrc mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• abnormal nasal potential difference
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes

growth/size/body
• reduced at 21 days of age relative to wild-type mice, but not at 7 or 14 days of age

digestive/alimentary system
N
• able to eat a solid diet without developing intestinal blockage

immune system
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Cystic Fibrosis; CF 219700 J:112450


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory