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Phenotypes Associated with This Genotype
Genotype
MGI:3689380
Allelic
Composition
Cftrtm2Mrc/Cftrtm2Mrc
Genetic
Background
B6.129S6-Cftrtm2Mrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm2Mrc mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• able to eat a solid diet without developing intestinal blockage

growth/size/body
• did not differ significantly from wild-type controls at 7 days of age (P 0.05) but weighed significantly less than controls at 21 days of age

hematopoietic system
• lower relative neutrophil numbers
• greater absolute alveolar macrophage numbers

immune system
• lower relative neutrophil numbers
• greater absolute alveolar macrophage numbers
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

mortality/aging
• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

respiratory system
• greater absolute alveolar macrophage numbers
• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftrtm1Unc homozygotes
• after treatment with a chloride-depleted solution with amiloride and forskolin, the nasal potential difference (PD) was significantly different between control mice and homozygous mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cystic Fibrosis; CF 219700 J:112450


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory