Phenotypes Associated with This Genotype

Genotype
MGI:3689377

• Allelic Composition: Epha2^{Gt(KST085)Byg}/Epha2^{Gt(KST085)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Development of progressive cataract in Epha2^{Gt(KST085)Byg}/Epha2^{Gt(KST085)Byg} mice

neoplasm

increased incidence of tumors by chemical induction ( J:112120 )

• following skin tumor initiation and promotion by DMBA and TPA tumor latency is decreased by 2 - 3 weeks, tumor incidence is increased 7 fold at 10 weeks after onset of treatment, and tumor growth is increased

• proliferation of skin tumor cells is increased

increased metastatic potential ( J:112120 )

• following a skin tumor initiation and promotion protocol using DMBA and TPA for 16 weeks the rate of malignant conversion of tumors is about twice that of wild-type mice

vision/eye

cortical cataract ( J:151310 )

• mice develop progressive cortical cataracts

• onset of lens opacity occurs as early as 1 month of age

• bilateral lens opacity is observed at 5 months unlike in wild-type mice

• mature cataracts with lens rupture occurs between 6 and 8 months

• by 12 months, over 80% of mice exhibit cataracts

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:112120 )

• following skin tumor initiation and promotion by DMBA and TPA tumor latency is decreased by 2 - 3 weeks, tumor incidence is increased 7 fold at 10 weeks after onset of treatment, and tumor growth is increased

• proliferation of skin tumor cells is increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 6 multiple types		DOID:0110229	OMIM:116600	J:151310