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Phenotypes Associated with This Genotype
Genotype
MGI:3689305
Allelic
Composition		 Vav1tm1Tyb/Vav1tm1Tyb
Genetic
Background		 C.129S2-Vav1tm1Tyb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1tm1Tyb mutation (2 available); any Vav1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal negative T cell selection ( J:79323 )
• deletion of CD4+ cells expressing Vbeta3, 5, and 11 is less than in wild-type mice suggesting impaired negative selection

hematopoietic system
abnormal negative T cell selection ( J:79323 )
• deletion of CD4+ cells expressing Vbeta3, 5, and 11 is less than in wild-type mice suggesting impaired negative selection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory