Phenotypes Associated with This Genotype

Genotype
MGI:3689304

• Allelic Composition: Vav1^tm1Tyb/Vav1^tm1Tyb
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:79323 )

• about a 50% reduction in cell number

decreased thymocyte number ( J:86654 )

abnormal double-negative T cell morphology ( J:79323 )

• while the overall absolute number of double negative cells is similar to wild-type as are the numbers of early stage double negative cell subpopulation, the number of CD44-CD25+ cells is increased about 2-fold

decreased double-positive T cell number ( J:79323 )

• reduced about 2-fold

decreased mature B cell number ( J:86654 )

• small decrease in mature IgM^loIgD^hi B cells

decreased single-positive T cell number ( J:79323 )

• about a 7- to 10-fold reduction in the number of single positive cells is seen in the thymus and in peripheral T cell populations in the spleen and lymph nodes

abnormal T cell physiology ( J:79323 , J:86654 )

• greatly reduced T cell receptor-induced calcium fluxes (J:79323)

• calcium fluxes induced by anti-CD3 antibody cross-linking are diminished in T cells (J:86654)

decreased T cell proliferation ( J:86654 )

• T cells show a partial defect in proliferative responses to stimulation with anti-CD3 with or without anti-CD28 antibodies

• ability of T cells to generate blasts when stimulated is reduced by 3- to 4-fold

decreased interferon-gamma secretion ( J:86654 )

• production of IFN-gamma by T cells in response to TCR stimulation is reduced

decreased interleukin-2 secretion ( J:86654 )

• production of IL-2 by T cells in response to TCR stimulation is reduced

hematopoietic system

thymus hypoplasia ( J:79323 )

• about a 50% reduction in cell number

decreased thymocyte number ( J:86654 )

abnormal double-negative T cell morphology ( J:79323 )

• while the overall absolute number of double negative cells is similar to wild-type as are the numbers of early stage double negative cell subpopulation, the number of CD44-CD25+ cells is increased about 2-fold

decreased double-positive T cell number ( J:79323 )

• reduced about 2-fold

decreased mature B cell number ( J:86654 )

• small decrease in mature IgM^loIgD^hi B cells

decreased single-positive T cell number ( J:79323 )

• about a 7- to 10-fold reduction in the number of single positive cells is seen in the thymus and in peripheral T cell populations in the spleen and lymph nodes

abnormal T cell physiology ( J:79323 , J:86654 )

• greatly reduced T cell receptor-induced calcium fluxes (J:79323)

• calcium fluxes induced by anti-CD3 antibody cross-linking are diminished in T cells (J:86654)

decreased T cell proliferation ( J:86654 )

• T cells show a partial defect in proliferative responses to stimulation with anti-CD3 with or without anti-CD28 antibodies

• ability of T cells to generate blasts when stimulated is reduced by 3- to 4-fold

endocrine/exocrine glands

thymus hypoplasia ( J:79323 )

• about a 50% reduction in cell number

decreased thymocyte number ( J:86654 )

cellular

decreased T cell proliferation ( J:86654 )

• T cells show a partial defect in proliferative responses to stimulation with anti-CD3 with or without anti-CD28 antibodies

• ability of T cells to generate blasts when stimulated is reduced by 3- to 4-fold